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Thursday, January 31, 2013

Stocks end lower after GDP data released

1 hr.

Javier E. David , CNBC

Major U.S. stock benchmarks fell on Wednesday, after dour U.S. growth data reinforced a decision by the?Federal Reserve?to maintain its commitment to massive economic stimulus.

In a decision widely expected by analysts, the Fed emphasized that it would stick to its bond-buying program. That outcome was cast into doubt just weeks ago, after minutes from the central bank's last policy meeting showed some Fed members were growing concerned about ultra-low borrowing costs.

The decision converged with data that showed the U.S. economy?shrank by an annualized?0.1 percent in the final three months of 2012, and reinforced expectations that the Fed would likely err on the side of more stimulus.

Despite a run of strong corporate earnings, the GDP data fanned concerns about the economy's ability to absorb higher tax rates ? some of which took effect when the payroll tax holiday expired at the beginning of the year ? and efforts to cut government spending.

"The real risk out there, and the Fed was very vague in how they characterized it?I think we're going to see major government spending cuts that are going to come through sequestration," Diane Swonk, chief economist and senior managing director,?Mesirow Financial, told CNBC's "Street Signs"

"That is something the Fed has to deal with. That not only means weaker growth, which justifies lower rates, but it also means more Fed action."

After floating for most of the session between modest gains and losses in directionless trading, the Dow Jones Industrial Average shed about 44 points, trading around 13,910.19, drifting further away from the psychologically-important 14,000 barrier being watched by analysts.

The S&P 500 Index slipped by nearly six points to 1,501.93, while the the Nasdaq dipped five points to trade above 3,142.31.

The CBOE Volatility Index (VIX), widely considered to be the market's best gauge of fear in the market, rose above just shy of 14.

After floating for most of the session between modest gains and losses in directionless trading, the?Dow Jones Industrial Average?shed about 44 points, trading around 13,910.19, drifting further away from the psychologically-important 14,000 barrier being watched by analysts.

The?S&P 500?Index slipped by nearly six points to 1,501.93, while the the?Nasdaq?dipped five points to trade above 3,142.31.

The?CBOE Volatility Index (VIX), widely considered to be the market's best gauge of fear in the market, rose above just shy of 14.

Meanwhile, after weeks of buying on the rumor of?Research In Motion's new BlackBerry 10, investors on Wednesday opted to sell the fact.

The company ? which officially changed its corporate name to BlackBerry ? unveiled the new smartphone that many analysts see as essential to its long-term survival. Still, investors voted with their feet as RIM shares?plunged more than ten percent in volatile trading. It finished the session near near $14.

Volume in the company's stock this month is 85 percent higher than the average daily volume in the previous three months, 34.2 million. RIM?shares?are?up about 29 percent this month, its largest gain?since November, when it rose 46 percent.

The GDP report came just on the heels of a policy decision by the Fed. Some analysts, however, saw the slippage in U.S. growth as a temporary blip.

"[The] bottom line is that while this is the first reading for output for the final quarter, both inventories and trade could be revised firmer," said Andrew Wilkinson, chief economic strategist at?Miller Tabak.

"We expect 2013 to start with a rebound in inventory building, something evidenced by firm durable goods orders that will likely filter through into shipments moving into" the first quarter of this year, he added.

Still, markets were encouraged by a spate of strong quarterly earnings reports.?Boeing?rose one percent after the company reported fourth-quarter profit of?$1.28 per share, above analyst estimates. The company dismissed speculation that its bottom line would take a hit from widely publicized problems with its 787 Dreamliner, and expects to maintain its production and delivery forecast.

Amazon.com?surged by more than four percent, trading near $270 and within striking distance of a new 52-week high despite seeing a?fourth-quarter shortfall?on both the top and bottom lines. Analysts preferred to focus instead on what they expect will be Amazon's impressive profit margins.

Looking ahead, social networking giant Facebook notched gains ahead of its fourth quarter earnings, scheduled to be released after the bell. After broad pessimism pushed its stock below $20 last year, the company's stock has steadily climbed back above $30.

Source: http://www.nbcnews.com/business/stocks-end-lower-after-gdp-data-released-1B8183010

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Wednesday, January 30, 2013

Academic gains, improved teacher relationships found among high risk kids in Head Start

Jan. 30, 2013 ? A new study by Oregon State University researchers finds that Head Start can make a positive impact in the lives of some of its highest risk children, both academically and behaviorally.

Published in the current issue of the Journal of Applied Developmental Psychology, the study sheds light on how Head Start has helped children living in non-parental care, or living with someone who is not a parent or step-parent by biology or adoption.

"These children tend to have unstable home lives, sometimes transitioning between different relatives, living with their grandma one month, and later with an aunt or other family member," said lead author Shannon Lipscomb, an assistant professor of human development and family sciences at OSU-Cascades.

"These are kids who face heightened risk factors even beyond those of other children living in poverty. They are more similar to what we find in kids in child welfare. They have a lot of challenges in their lives, and the stresses of that can cause behavioral and development issues."

The researchers obtained data from the Head Start Impact Study, a nationally representative sample of Head Start programs and families commissioned by the federal government. Head Start provides comprehensive early child development services to low-income children and their families. That original study, published in 2010, looked at the general population of children attending Head Start programs, but did not examine impacts for children living in non-parental care.

"Children in non-parental care showed more problems with academics, behavior, and a wide variety of risk factors at the beginning of the study," Lipscomb said. "In addition, Head Start is designed as a wrap-around program, which links child, teacher, and parent. So we wanted to know if this model even works for kids who don't have a traditional family, and may have different caregivers at any given time."

The researchers found that Head Start appears to be as beneficial for this group of children as it is for the general population of children living in poverty who attend the program. Analyzing the data on 253 children in non-parental care, they found the program had short-term positive impacts on school readiness, particularly in regards to early academic skills, positive teacher-child relationships, and a reduction in behavior problems.

"Our findings show Head Start is at least as effective for this very high risk group as prior studies have shown that it is for other children," Lipscomb said. "The impact we saw was modest, not huge, but statistically significant. We think the positive impact on child-teacher relationships is especially important."

Lipscomb said this was a new finding; prior analysis of Head Start's impacts on children who live with their parents haven't found this effect.

Lipscomb is an expert on early childhood development, with an emphasis on preschool and early child care experiences, and how those early social experiences help kids prepare for success in life. Her work focuses on children from at-risk backgrounds.

"Children in non-parental care tend to struggle with socio-emotional development, likely due to the risk factors they experience such as transitioning between homes, special needs, and behavioral problems," she said. "Perhaps as a result of Head Start's whole-child focus and standards for teacher qualifications, their teachers may be more effective than caregivers in other types of programs in establishing positive relationships with children who have high needs."

OSU doctoral students Megan Pratt and Sara Schmitt, as well as Katherine Pears and Hyoun Kim of the Oregon Social Learning Center, contributed to this study.

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The above story is reprinted from materials provided by Oregon State University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Shannon T. Lipscomb, Megan E. Pratt, Sara A. Schmitt, Katherine C. Pears, Hyoun K. Kim. School readiness in children living in non-parental care: Impacts of Head Start. Journal of Applied Developmental Psychology, 2013; 34 (1): 28 DOI: 10.1016/j.appdev.2012.09.001

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/i8MOfHgA7lM/130130121654.htm

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Alex Rodriguez named in a new doping report

A man in south Florida supplied performance-enhancing drugs to more than half a dozen major league players, including Alex Rodriguez, according to a Miami New Times report that officials at Major League Baseball believe will grow into a doping scandal that could rival the BALCO case that tarnished Barry Bonds.

Alex Rodriguez is once again at the center of a possible PED scandal. (AP Photo) The newspaper reported Tuesday morning that Anthony Bosch, a self-styled biochemist seen frequently in Latin American baseball circles, distributed large amounts of human growth hormone, synthetic testosterone and other cocktails of PEDs to players who previously had not been linked, such as Texas Rangers outfielder Nelson Cruz. Some of the players could be subject to a 50-game suspension for a violation of the league's PED policy, a league official told Yahoo! Sports. Three of Bosch's alleged clients ? outfielder Melky Cabrera, pitcher Bartolo Colon and catcher Yasmani Grandal ? already have been caught and suspended by the league. Following a relatively quiet period, PED busts spiked in baseball last season. From Ryan Braun's positive test for testosterone ? which got overturned because of alleged mishandling of evidence ? to the suspensions of Cabrera, Colon, Grandal, Freddy Galvis, Marlon Byrd, Guillermo Mota and Carlos Ruiz, baseball is facing a renaissance of use, one it believes centered in south Florida. While MLB had investigated wellness clinics and other suspected PED purveyors in the Miami area, it had not uncovered much of the blockbuster information revealed in the New Times story, the official told Yahoo! Sports. [Also: Texas hopes to replace Josh Hamilton with prospects]

The records of players' use, given to the New Times by a former employee at Bosch's Biogenesis clinic, are especially detailed in the cases of Rodriguez and Cabrera. Rodriguez, referred to as "Alex Rodriguez," "Alex Rod" or "Cacique," received HGH, testosterone cream and insulin-like growth factor, all banned under MLB's PED policy. He also was given "troches," a lozenge that has 15 percent testosterone, and other types of growth hormone, according to the report.

Rodriguez's account was "paid through April 30th" of 2012, according to the records. Cruz, the slugging outfielder whom Bosch nicknamed "Mohamad," gave Bosch $4,000 in July 2012, the records said, for a regimen that included "troches." The report also links Washington Nationals left-hander Gio Gonzalez to Bosch, though the five mentions of him in the records are less specific. While they include a $1,000 charge, Gonzalez's father, Max, said he was the one working with Bosch to lose weight. Florida state and federal authorities have amped up their inquiries into Bosch in recent months, the league official said, as he operated a number of clinics that catered to athletes as well as the growing group that seeks HGH and testosterone as anti-aging treatments. [Also: Milwaukee Brewers will wear fan-designed uniform]

Pedro Bosch, a doctor who has worked in Florida for more than 35 years and is Anthony's father, supplied the fertility-drug prescription to Manny Ramirez that prompted his first PED suspension in 2009.

While the Drug Enforcement Agency looked into the Bosches supplying the players, it chose not to pursue a case, according to ESPN.com. MLB and the players association strengthened the league's PED policy this offseason, instituting random blood testing for HGH and a stronger test for synthetic testosterone triggered by a variation from a baseline testosterone-to-epitestosterone ratio the league will keep on every player. Other popular content on Yahoo! Sports:
? Ray Lewis dealing with pain of ailing grandmother
? Colin Kaepernick taking silence-is-golden approach to media circus
? Why J.J. Redick had to attend Justin Bieber show
? Man U fan gets unwanted attention after peeing on Mario Balotelli's car

Source: http://news.yahoo.com/alex-rodriguez-is-the-biggest-name-in-a-new-ped-report-that-could-rival-balco-143803741.html

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3D Systems, Stratasys Retrench As ExOne Sets IPO ... - Investors.com

The two leading makers of three-dimensional printers sold off with gusto Monday. 3D Systems (DDD) led the rock slide, losing 14% in five times its average trade.

Peer Stratasys (SSYS) shed 10% on a big volume bump.

Stratasys stopped at its 50-day moving average and 3D Systems stopped well above its 50-day line. The level of selling in both stocks was serious. In 3D's case, shares fell on the highest volume since a breakout in April.

The main news in the sector came from 3D printing company ExOne, which set terms Monday for its $75 million initial public offering.

The Pennsylvania-based company, which provides printing machines and printed products to industrial customers, plans to sell 5 million shares priced between 14 and 16. The company plans to list on the Nasdaq under the symbol XONE.

Its printers reportedly offer fast, low-cost prototypes made from metal, glass or ceramic powder. But there is no clear read yet, analysts say, on how the new and much smaller entrant may affect the competitive field.

The news arrived just as 3D Systems shares had reached a bit of a precarious position. The stock gapped up 5% last week, breaking above an upper channel line ? a line drawn across the highs since May .

A break above this line is a sell signal, a sign the stock's run may be weakening. In the case of 3D Systems, the signal's importance is compounded by the fact the stock has already broken out of a third-stage base.

Also, shares rose 86% above their 200-day moving average last week. Advances of 70% to 100% above a stock's 200-day moving average may also warn of weakness in a stock's uptrend.

Analysts' consensus forecast for the company's earnings is an increase of 138% in Q4 on a 49% gain in sales. The company will report before the market opens Feb. 25.

Stratasys is also above a third-stage base but it has given up most gains from its November breakout. It had run up as much as 33% from its buy point, vs. a 60% advance for 3D Systems.

Source: http://news.investors.com/investing-ibd-industry-themes/012813-642205-3d-systems-and-stratsys-sell-off.htm

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Obama launches push for immigration overhaul

Sen. Marco Rubio, R-Fla.. center, answers a reporter's question as he and a bipartisan group of leading senators announce that they have reached agreement on the principles of sweeping legislation to rewrite the nation's immigration laws, during a news conference at the Capitol in Washington, Monday, Jan. 28, 2013. From left are Sen. John McCain, R-Ariz., Sen. Charles Schumer, D-N.Y., Sen. Marco Rubio, R-Fla., and Sen. Robert Menendez, D-N.J. The deal covers border security, guest workers and employer verification, as well as a path to citizenship for the 11 million illegal immigrants already in this country. (AP Photo/J. Scott Applewhite)

WASHINGTON (AP) ? Seeking swift action on immigration, President Barack Obama on Tuesday will try to rally public support behind his proposals for giving millions of illegal immigrants a pathway to citizenship, as well as making improvements to the legal immigration system and border security.

The president will launch his push in a campaign-style event in Las Vegas, a day after a bipartisan group of senators unveiled their own plan for addressing an issue that has languished in Washington for years.

Administration officials said Obama would largely endorse the senators' efforts, though immigration advocates said they expected the president's own proposals to be more progressive than the Senate group's, including a faster pathway to citizenship.

The simultaneous immigration campaigns were spurred by the November presidential election, in which Obama won an overwhelming majority of Hispanic voters. The results caused Republican lawmakers who had previously opposed immigration reform to reconsider in order to rebuild the party's reputation among Hispanics, an increasingly powerful political force.

Most of the recommendations Obama will make Tuesday are not new. He outlined an immigration blueprint in May 2011 but exerted little political capital to get it passed by Congress, to the disappointment of many Hispanics.

Obama "believes that we are at a moment now where there seems to be support coalescing at a bipartisan level behind the very principles that he has long put forward and behind principles that have in the past enjoyed bipartisan support," White House press secretary Jay Carney said Monday. "And that is a very positive thing."

The president was to make his pitch in Nevada, a political battleground he carried in November, in large part because of support from Hispanics in the state.

Nationally, Obama won 71 percent of the Hispanic vote, giving him a key advantage over Republican rival Mitt Romney.

Administration officials said the president would bolster his 2011 immigration blueprint with some fresh details. His original plan centered on four key areas: a pathway to citizenship for the 11 million illegal immigrants in the U.S., improved border security, an overhaul of the legal immigration system, and an easier process for businesses to verify the legal status of workers.

Administration officials said they were encouraged to see the Senate backing the same broad principles. In part because of the fast action on Capitol Hill, Obama does not currently plan to send lawmakers formal immigration legislation.

However, officials said the White House does have legislation drafted and could fall back on it should the Senate process stall. The officials spoke on the condition of anonymity in order to discuss internal strategy.

Gay and lesbian advocates were also expecting Obama's proposals to include recognition of same-sex couples where one partner is American and another is not.

Obama's previous proposals for creating a pathway to citizenship required those already in the U.S. illegally to register with the government and submit to security checks; pay registration fees, a series of fines and back taxes; and learn English. After eight years, individuals would be allowed to become legal permanent residents and could eventually become citizens five years later.

The Senate group's pathway to citizenship for illegal immigrants already in the U.S. would be contingent upon securing the border and improving tracking of people in the U.S. on visas. Linking citizenship to border security could become a sticking point between the White House and lawmakers.

The Senate framework would also require those here illegally to pass background checks and pay fines and taxes in order to qualify for a "probationary legal status" that would allow them to live and work here ? but not qualify for federal benefits ? before being able to apply for permanent residency, a critical step toward citizenship. Once they are allowed to apply they would do so behind everyone else already waiting for a green card within the current immigration system.

Passage of legislation by the full Democratic-controlled Senate is far from assured, but the tallest hurdle could come in the House, which is dominated by conservative Republicans who've shown little interest in immigration reform.

The senators involved in formulating the immigration proposals were Democrats Charles Schumer of New York, Dick Durbin of Illinois, Robert Menendez of New Jersey and Michael Bennet of Colorado; and Republicans John McCain of Arizona, Lindsey Graham of South Carolina, Marco Rubio of Florida and Jeff Flake of Arizona.

Several of these lawmakers have worked for years on the issue. McCain collaborated with the late Democratic Sen. Edward M. Kennedy on comprehensive immigration legislation pushed by then-President George W. Bush in 2007, only to see it collapse in the Senate when it couldn't get enough GOP support.

___

Associated Press writer Erica Werner contributed to this report.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-29-Obama/id-44af5aa8ca564744bc9c806c7c4cfe95

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Tuesday, January 29, 2013

Caterpillar 4Q earnings fall by half

MINNEAPOLIS (AP) ? Caterpillar's fourth-quarter net income fell by half after it took a big charge for a deal in China that went bad, and because of slower growth in China and economic uncertainty in the U.S. and Europe.

Still, its adjusted profit and revenue were better than analysts expected. And while cautious about the global economic outlook, Caterpillar does expect conditions to pick up later in the year, outside of Europe. Shares rose 2.4 percent in premarket trading.

Caterpillar Inc. makes construction and mining equipment as well as power generators, so its growth rises and falls with the world's economy.

For the fourth quarter, Caterpillar earned $697 million, or $1.04 per share. That was down from a profit of $1.55 billion, or $2.32 per share a year earlier.

Revenue fell 7 percent to $16.08 billion as dealers reduced inventory.

The most recent quarter included a non-cash charge of 87 cents per share to write down the purchase of Zhengzhou Siwei. Not counting that, analysts surveyed by FactSet had been expecting a profit of $1.70 per share.

Caterpillar's purchase of Siwei last year gave it a new business ? roofing supports for mines ? in a country where mining is growing quickly. But on Jan. 18, Caterpillar said it had found "deliberate, multi-year, coordinated accounting misconduct" in the accounting at Siwei, and said it will write down its investment in the company by $580 million. It also said it dismissed several senior managers at the company.

For this year, Caterpillar expects revenue of $60 billion to $68 billion, with a profit of $7 to $9 per share.

Analysts had been expecting a profit of $8.54 per share on revenue of $64.58 billion.

Caterpillar said there's a wide range in its outlook because of the high level of uncertainty in the world. It expects relatively weak growth in the U.S. economy. Growth in China will improve, but not back to the levels seen in 2010 or 2011, Caterpillar said.

For all of 2012, the company's profits rose 15 percent to $5.68 billion, or $8.48 per share, up from $4.93 billion, or $7.40 per share, in 2011. Revenue rose 10 percent to $65.88 billion, from $60.14 billion.

Shares of the Peoria, Ill.-based company rose $2.32 to $97.90 in premarket trading.

Source: http://news.yahoo.com/caterpillar-4q-earnings-fall-half-130355098--finance.html

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Patients' own skin cells are transformed into heart cells to create 'disease in a dish'

Monday, January 28, 2013

Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem. With this technology, researchers can generate heart muscle cells from a patient's own skin cells. However, these newly made heart cells are mostly immature. That raises questions about whether or not they can be used to mimic a disease that occurs in adulthood. In a paper published January 27 in Nature, researchers at Sanford-Burnham Medical Research Institute and Johns Hopkins University unveil the first maturation-based "disease in a dish" model for ARVD/C. The model was created using Yamanaka's technology and a new method to mimic maturity by making the cells' metabolism more like that in adult hearts. For that reason, this model is likely more relevant to human ARVD/C than other models and therefore better suited for studying the disease and testing new treatments.

"It's tough to demonstrate that a disease-in-a-dish model is clinically relevant for an adult-onset disease. But we made a key finding here?we can recapitulate the defects in this disease only when we induce adult-like metabolism. This is an important breakthrough considering that ARVD/C symptoms usually don't arise until young adulthood. Yet the stem cells we're working with are embryonic in nature," said Huei-Sheng Vincent Chen, M.D., Ph.D., associate professor at Sanford-Burnham and senior author of the study.

To establish this model, Chen teamed up with expert ARVD/C cardiologists Daniel Judge, M.D., Joseph Marine, M.D., and Hugh Calkins, M.D., at Johns Hopkins University. Johns Hopkins is home to one of the largest ARVD/C patient registries in the world.

"There is currently no treatment to prevent progression of ARVD/C, a rare disorder that preferentially affects athletes. With this new model, we hope we are now on a path to develop better therapies for this life-threatening disease," said Judge, associate professor and medical director of the Center for Inherited Heart Disease at the Johns Hopkins University School of Medicine.

Disease in a dish

To recreate a person's own unique ARVD/C in the lab, the team first obtained skin samples from ARVD/C patients with certain mutations believed to be involved in the disease. Next they performed Yamanaka's technique: adding a few molecules that dial back the developmental clock on these adult skin cells, producing embryonic-like induced pluripotent stem cells (iPSCs). The researchers then coaxed the iPSCs into producing an unlimited supply of patient-specific heart muscle cells. These heart cells were largely embryonic in nature, but carried along the original patient's genetic mutations.

However, for nearly a year, no matter what they tried, the team couldn't get their ARVD/C heart muscle cells to show any signs of the disease. Without actual signs of adult-onset ARVD/C, these young, patient-specific heart muscle cells were no use for studying the disease or testing new therapeutic drugs.

Speeding up time

Eventually, the team experienced the big "aha!" moment they'd been looking for. They discovered that metabolic maturity is the key to inducing signs of ARVD/C, an adult disease, in their embryonic-like cells. Human fetal heart muscle cells use glucose (sugar) as their primary source of energy. In contrast, adult heart muscle cells prefer using fat for energy production. So Chen's team applied several cocktails to trigger this shift to adult metabolism in their model.

After more trial and error, they discovered that metabolic malfunction is at the core of ARVD/C disease. Moreover, Chen's team tracked down the final piece of puzzle to make patient-specific heart muscle cells behave like sick ARVD/C hearts: the abnormal over-activation of a protein called PPAR?. Scientists previously attributed ARVD/C to a problem in weakened connections between heart muscle cells, which occur only in half of the ARVD/C patients. With the newly established model, they not only replicated this adult-onset disease in a dish, but also presented new potential drug targets for treating ARVD/C.

What's next?

Chen's team was recently awarded a new grant from the California Institute for Regenerative Medicine to create additional iPSC-based ARVD/C models. With more ARVD/C models, they will determine whether or not all (or at least most) patients develop the disease via the same metabolic defects discovered in this current study.

Together with the Johns Hopkins team, Chen also hopes to conduct preclinical studies to find a new therapy for this deadly heart condition.

###

Sanford-Burnham Medical Research Institute: http://www.burnham-inst.org

Thanks to Sanford-Burnham Medical Research Institute for this article.

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Source: http://www.labspaces.net/126483/Patients__own_skin_cells_are_transformed_into_heart_cells__to_create__disease_in_a_dish_

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